Recombinant Mouse TREML2 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse TREML2 protein His25-Ala270 (Accession# Q2LA85) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 328833 |
| 蛋白编号 | Q2LA85 |
| 预测分子量 | 53.1 kDa |
| SDS-PAGE | 80-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Triggering receptor expressed on myeloid cells-like protein 2 (TREML2) is a cell-surface receptor participating in innate and adaptive immune responses. It functions as a counter-receptor for CD276, and its binding to CD276 on T cells potentiates T-cell activation. Upregulating TREML2 represents a potential novel therapeutic strategy to alleviate doxorubicin resistance in acute myeloid leukemia.
参考文献:
1. Allcock, Richard J N et al. European journal of immunology vol. 33,2 (2003): 567-77. 2. Hashiguchi, Masaaki et al. Proceedings of the National Academy of Sciences of the United States of America vol. 105,30 (2008): 10495-500. 3. Zhang, Xin et al. Blood science (Baltimore, Md.) vol. 7,2 (2025): e00223.
