Recombinant Human ENPP2/Autotaxin protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human ENPP2 protein Asp49-Ile863 (Accession# Q13822-1) with a rabbit IgG Fc tag at the N-terminus. |
| 基因ID | 5168 |
| 蛋白编号 | Q13822-1 |
| 预测分子量 | 119.8 kDa |
| SDS-PAGE | 105-135 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
ENPP2, Autotaxin or Extracellular lysophospholipase D, is a 863 amino acid secreted protein, which is detected in blood plasma (at protein level). ENPP2 is Predominantly expressed in brain, placenta, ovary, and small intestine. ENPP2 is expressed in a number of carcinomas such as hepatocellular and prostate carcinoma, neuroblastoma and non-small-cell lung cancer. ENPP2 is expressed in body fluids such as plasma, cerebral spinal fluid (CSF), saliva, follicular and amniotic fluids. ENPP2 Hydrolyzes lysophospholipids to produce the signaling molecule lysophosphatidic acid (LPA) in extracellular fluids.
参考文献:
1.Tokumura, Akira et al. The Journal of biological chemistry vol. 277,42 (2002): 39436-42. 2.Stein, Adam J et al. Molecular pharmacology vol. 88,6 (2015): 982-92. 3.van Meeteren, Laurens A et al. The Journal of biological chemistry vol. 280,22 (2005): 21155-61. 4.Stein, Adam J et al. Molecular pharmacology vol. 88,6 (2015): 982-92. 5.Bain, Gretchen et al. The Journal of pharmacology and experimental therapeutics vol. 360,1 (2017): 1-13.
