Recombinant Human MYO18A protein (mFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human MYO18A protein Glu220-Pro331 (Accession# Q92614-1) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 399687 |
| 蛋白编号 | Q92614-1 |
| 预测分子量 | 38.9 kDa |
| SDS-PAGE | 39-45 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
MYO18A is an unconventional myosin that may play a role in the stabilization and organization of the actin cytoskeleton. Recently MYO18A has been identified as the receptor of SP and is responsible for clearance of SP-A-opsonized bacteria in in vivo infection. Two different isoforms of mouse Myo18A have been identified: Myo18A-alpha and Myo18A-beta as 230- and 190-kDa proteins, respectively. Myo18a-alpha colocalizes with the ER-Golgi complex and with membrane ruffles and filopodia, while Myo18a-beta localizes diffusely to the cytoplasm.
参考文献:
1.Buschman, Matthew D, and Seth J Field. Advances in biological regulation vol. 67 (2018): 84-92. 2.Sever-Chroneos, Zvjezdana et al. The Journal of biological chemistry vol. 286,6 (2011): 4854-70. 3.Mori, Kentaro et al. Journal of biochemistry vol. 133,4 (2003): 405-13.
