Recombinant Human ROBO1 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human ROBO1 protein Gln26-Pro897 (Accession# Q9Y6N7-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 6091 |
| 蛋白编号 | Q9Y6N7-1 |
| 预测分子量 | 121.2 kDa |
| SDS-PAGE | 115-150 kDa , reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
ROBO1 (Roundabout Guidance Receptor 1) is a type I single-pass transmembrane glycoprotein of the immunoglobulin superfamily, serving as the receptor for SLIT1/2 ligands. It mediates axon guidance, neuronal migration, and angiogenesis during development. Dysregulated ROBO1 drives tumor invasion/metastasis in multiple cancers and pathological ocular neovascularization. It is a preclinical therapeutic target; neutralizing antibodies and small molecules blocking SLIT-ROBO1 signaling are under investigation for cancer and eye diseases.
参考文献:
1. Hannula-Jouppi, Katariina et al. PLoS genetics vol. 1,4 (2005): e50. 2. Bhosle, Vikrant K et al. Nature communications vol. 11,1 4112. 17 Aug. 2020.
