Recombinant Human PICAL protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human PICAL protein Ser2-Met652 (Accession# Q13492-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 8301 |
| 蛋白编号 | Q13492-1 |
| 预测分子量 | 96.2 kDa |
| SDS-PAGE | 100-140 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
PICALM (Phosphatidyl Inositol Clathrin Assembly Lymphoid Myeloid protein) is a ubiquitously expressed protein that plays a role in clathrin-mediated endocytosis. PICALM also affects the internalization and trafficking of SNAREs and modulates macroautophagy. PICALM is a highly validated genetic risk factor for Alzheimer's disease (AD). The long isoform of human PICALM has 22 exons (encoding PICALML), while the short isoform lacks exon 14 (encoding PICALMS).
参考文献:
1.Zhang, Feifei et al. Molecular cancer vol. 20,1 6. 4 Jan. 2021. 2.Mercer, Jacob L et al. PloS one vol. 10,6 e0129776. 15 Jun. 2015. 3.Zhao, Zhen et al. Nat Neurosci. 2015;18(7):978-987.
