Recombinant Human CRH/CRF protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CRH protein Leu25-Ile194 (Accession# P06850) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 1392 |
| 蛋白编号 | P06850 |
| 预测分子量 | 44.8 kDa |
| SDS-PAGE | 43-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in 0.5M arg，30mM Tris，pH8.0. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CRH, also called CRF or corticoliberin, is a peptide hormone and neurotransmitter involved in the stress response. Marked reduction in this protein has been observed in association with Alzheimer disease. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery.
参考文献:
1. Makrigiannakis A, et al. (2018) Curr Mol Pharmacol. 11(1):81-87. 2. Zhu C, Li S. (2024) Front Endocrinol (Lausanne). 15:1363748. 3. Bamberger CM, Bamberger AM. (2000) Ann N Y Acad Sci. 917:290-296. 4. Rassouli O, et al. (2018) Curr Mol Pharmacol. 11(1):72-80.
