Recombinant Human A2ML1 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human A2ML1 protein Glu18-Glu1454 (Accession# A8K2U0) with a rabbit IgG Fc tag at the N-terminus. |
| 基因ID | 144568 |
| 蛋白编号 | A8K2U0 |
| 预测分子量 | 186.5 kDa |
| SDS-PAGE | 150-250 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
A2ML1 is a monomeric protease inhibitor belonging to the A2M superfamily of protease inhibitors and complement factors. A2ML1 is abundant in the epidermal granular layer of the skin but is also found in the placenta, thymus, and testis. Similar to the functional characteristics of A2Ms, the A2ML1 protein can inhibit extracellular protease through a unique “capture” mechanism, thereby contributing significantly to epithelial cell desquamation. Moreover, A2ML1 can regulate epithelial cell homeostasis by interacting with growth factors and cytokines.
参考文献:
1.Nielsen, Nadia Sukusu et al. Nature communications vol. 13,1 (2022): 3033. 2.Zhang, Xiaoyun et al. Canadian journal of gastroenterology & hepatology vol. 2023 (2023): 5557546.
