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Recombinant Human LAIR2 protein (rFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg4247

Print datasheet

Synonyms

CD306, LAIR 2

验证数据展示

  • Purity of Recombinant Human LAIR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human LAIR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human LAIR2 was greater than 90% as determined by SEC-HPLC.

    The purity of Human LAIR2 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human LAIR2 protein Gln22-Pro152 (Accession# Q6ISS4-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 3904
蛋白编号 Q6ISS4-1
预测分子量 40.3 kDa
SDS-PAGE 42-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

LAIR2, or leukocyte-associated immunoglobulin-like receptor 2, is a protein that belongs to the immunoglobulin superfamily. It is highly expressed in the placenta, specifically in the extravillous trophoblasts (EVTs) at the leading edge of the anchoring cell columns invading the maternal decidua. LAIR2 expression has also been noted to be down-regulated in the first trimester of pregnancies destined for preeclampsia, suggesting a potential role in the etiology of this condition. LAIR2 has been implicated in cancer immunotherapy. A study suggests that LAIR-2 can act as a decoy receptor by binding collagen with higher affinity than LAIR-1, potentially releasing LAIR-1-mediated immune suppression. This could be a novel strategy for cancer immunotherapy, particularly for immune-excluded tumors.

参考文献:

1. Founds SA. et al. (2013) Placenta. 34(3):248-55.
2. Ramos MIP. et al. (2021) Elife. 10:e62927.
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