Recombinant Human RON/MST1R protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | CHO-derived Human RON protein Glu25-Leu571 (Accession# Q04912-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 4486 |
| 蛋白编号 | Q04912-1 |
| 预测分子量 | 84.9 kDa |
| SDS-PAGE | 30-33 kDa, 55-65 kDa and 90-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
RON, also known as CD136 or Macrophage-Stimulating Protein Receptor (MST1R), is a type I transmembrane protein belonging to the group B of the scavenger receptor cysteine-rich (SRCR) superfamily. It is primarily expressed on cells of epithelial origin, as well as on specific immune cells such as macrophages. Its activation occurs upon binding to its ligand, Macrophage-Stimulating Protein (MSP), which triggers intracellular signaling cascades. These pathways are critically involved in regulating key cellular processes including proliferation, migration, survival, and the inhibition of apoptosis. Under normal physiological conditions, CD136 signaling contributes to tissue repair, inflammation resolution, and maintaining epithelial homeostasis. However, dysregulated CD136 expression and signaling are strongly implicated in oncogenesis, where it promotes tumor growth, invasive metastasis, and confers resistance to conventional therapies in various carcinomas.
参考文献:
1. Kowal, Krzysztof et al. Folia histochemica et cytobiologica vol. 49,3 (2011): 365-74. 2. Kang, Chang Moo et al. Pancreas vol. 43,2 (2014): 183-9. 3. Huang, Lingtong et al. Frontiers in immunology vol. 11(2020): 569082.
