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Recombinant Human DcR2 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3487

Print datasheet

Synonyms

DCR2, CD264, Decoy receptor 2, TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D

验证数据展示

  • Purity of Recombinant Human DcR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human DcR2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human DcR2 protein Ala56-His211 (Accession# Q9UBN6) with a rabbit IgG Fc tag at the C-terminus.
基因ID 8793
蛋白编号 Q9UBN6
预测分子量 43.1 kDa
SDS-PAGE 45-70 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Decoy receptor 2 (DcR2) is one of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptors and suppresses TRAIL-induced apoptosis. Its expression, like the other three TRAIL receptors (i.e., DR4, DR5, and DcR1), is regulated by p53. Previous studies found that DcR2 was highly expressed in senescent tumor cells and was associated with the degree of tumor differentiation . DcR2 is also expressed in activated senescent hepatic stellate cell, which protects senescent cell from cytotoxicity, eventually resulting in liver fibrosis .

参考文献:

1.Chen, Jia et al. (2019) Biochemistry.44(5):1063-1074. 
2.Liu, Xiangguo et al. (2005) Biochemistry.65(20):9169-9175. 
3.Yao, Zhuotian et al. (2023) Biochemistry.113(1):e22004.