Recombinant Human PRNP protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human PRNP protein Lys23-Gly229 (Accession# P04156-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 5621 |
| 蛋白编号 | P04156-1 |
| 预测分子量 | 48.9 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
The major prion protein (PrP) is encoded by the prion protein-encoding gene (PRNP). PrP is widely expressed in a variety of tissues and is abundant in the nervous system and participates in neuronal growth and survival. PrP expression is strongly associated with immune infiltrating cells, immunosuppressive cell infiltration and immune checkpoint molecules. PrP is an immune-related prognostic marker that holds promise for predicting outcomes related to colorectal cancer immunotherapy.
参考文献:
1.Broce IJ. et al. (2023) Ann Clin Transl Neurol. 10(4):536-552. 2.Lin C. et al. (2023) PLoS One. 18(8):e0288091. 3.Chen H. et al. (2024) Front Cell Dev Biol. 12:1391873.