Recombinant Mouse PSAP/Prosaposin protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse PSAP protein Ser17-Asn557 (Accession# Q61207) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 19156 |
| 蛋白编号 | Q61207 |
| 预测分子量 | 85.8 kDa |
| SDS-PAGE | 90-100 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Psap (Prosaposin) is a highly conserved glycoprotein that is involved in the metabolism of various sphingolipids within the cell and can be secreted into plasma, breast milk, or cerebrospinal fluid.Prosaposin proteins are proteolytically cleaved to produce four different polypeptides called saposin A, B, C, or D, which are required for the hydrolysis of certain sphingolipids by lysosomal hydrolases. required for the hydrolysis of certain sphingolipids by lysosomal hydrolases, and whose mutation results in lysosomal hydrolase deficiency and subsequent lysosomal storage disease. (PMID: 33197249) PSAP overexpression is associated with poor prognosis and promotes tumorigenesis and cancer stem cell proliferation in subcutaneous and in situ models of glioma. In patients with mesenchymal glioblastoma, PSAP is a marker of poor prognosis, as its high expression has been found to shorten patients' overall survival.
参考文献:
1.Lin ZH, et al. Brain. 2021;144(1):e3. 2. Wen Z, et al. Pathol Res Pract. 2022;238:154027. 3. Pankaj Sharma et al. Science. 2024; 383,190-200.
