Recombinant Human SPARCL1 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human SPARCL1 protein Ile17-Phe664 (Accession# Q8N4S1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 8404 |
| 蛋白编号 | Q8N4S1 |
| 预测分子量 | 99.2 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
SPARCL1 (Secreted Protein Acidic and Rich in Cysteine-like 1) is an extracellular matrix glycoprotein that plays diverse roles in tissue repair, inflammation, and lipid metabolism. It is highly expressed in the brain and involved in the regulation of lipid metabolism and inflammation. SPARCL1 has been implicated in various diseases, including non-alcoholic steatohepatitis (NASH), where it promotes disease progression through upregulation of CCL2. Additionally, SPARCL1 regulates macrophage activation and exacerbates viral pneumonia by promoting pro-inflammatory responses. In cancer, SPARCL1 expression is often downregulated, and it has been identified as a potential prognostic biomarker in breast cancer.
参考文献:
1. Liu, Bin et al. The Journal of clinical investigation vol. 131,20 (2021): e144801. 2. Cheng, Xu et al. Journal of inflammation research vol. 16 (2023): 2121-2127. 3. Zhao, Gan et al. Nature communications vol. 15,1 (2024): 4235. 4. Xu, Xin-Yu et al. Oncology letters vol. 29,4 (2025): 196.