• All
  • Primary Antibodies
  • Conjugated Antibodies for IF
  • Conjugated Antibodies for FC
  • Secondary Antibodies
  • Antibody Labeling KitsNew
  • ELISA Kits
  • IHC Kits
  • Magnetic Cell Separation Kits
  • Cytokines & Growth Factors
  • Neutralizing/activating Antibodies
  • Nanobody-based Reagents
  • Accessory Products and Kits
  • Fusion Proteins
×
×
Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0

Recombinant Human KLK6 protein (rFc Tag) (HPLC verified)

种属

Human

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2826

Print datasheet

Synonyms

EC:3.4.21.-, Kallikrein-6, PRSS18, PRSS9, SP59

验证数据展示

  • Purity of Recombinant Human KLK6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human KLK6 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human KLK6 was greater than 90% as determined by SEC-HPLC.

    The purity of Human KLK6 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human KLK6 protein Glu17-Lys244 (Accession# Q92876-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 5653
蛋白编号 Q92876-1
预测分子量 51.2 kDa
SDS-PAGE 10 kDa, 44-50 kDa and 55-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Kallikrein-related peptidase 6 (KLK6) belongs to a family of serine proteases that are emerging as prevalent biomarkers of inflammatory and malignant diseases. Cell culture and preclinical animal model studies suggest that KLK6 may promote inflammation and autoimmunity via cleavage of the G protein–coupled protease-activated receptor 1 (PAR1) and PAR2.

参考文献:

1. Billi AC, et al. (2020). J Clin Invest. 130(6):3151-3157.
2. Oikonomopoulou K, et al. (2006). Biol Chem. 387(6):817–824. 
3. Radulovic M, et al. (2015). Neurobiol Dis. 83:75–89.