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Recombinant Human CCL13 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2818

Print datasheet

Synonyms

MCP4, MCP-4, C C motif chemokine 13, CCL 13, CCL-13

验证数据展示

  • Purity of Recombinant Human CCL13 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human CCL13 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human CCL13 protein Gln24-Thr98 (Accession# Q99616) with a rabbit IgG Fc tag at the C-terminus.
基因ID 6357
蛋白编号 Q99616
预测分子量 34.6 kDa
SDS-PAGE 36-40 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in 30mM Tris,500mM Arginine, pH 8.0. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CCL13 (MCP-4)is asecreted C–C chemokinethat recruitsmonocytes, eosinophils, and T cellsto inflammatory sites viaCCR2/CCR3/CCR5 signaling. It plays key roles inallergic inflammation,fibrosis, andimmune cell trafficking, linking innate and adaptive immune responses. Dysregulated CCL13 expression contributes toasthma, autoimmune inflammation, and tumor microenvironment remodeling, underscoring its function as both achemotactic mediatorandpro-fibrotic cytokine.

参考文献:

1. Li, Laifu et al. Frontiers in immunology vol. 14 1176639. 19 Apr. 2023, doi:10.3389/fimmu.2023.1176639
2. Mendez-Enriquez, E, and E A García-Zepeda. Inflammopharmacology vol. 21,6 (2013): 397-406. doi:10.1007/s10787-013-0177-5
3. Wang, Dan et al. Experimental dermatology vol. 30,5 (2021): 723-732. doi:10.1111/exd.14293
4. Yanaba, K et al. The British journal of dermatology vol. 162,2 (2010): 332-6. doi:10.1111/j.1365-2133.2009.09507.x
5. Iwamoto, T et al. Rheumatology (Oxford, England) vol. 45,4 (2006): 421-4. doi:10.1093/rheumatology/kei209
6. Hintzen, Christoph et al. Arthritis and rheumatism vol. 60,7 (2009): 1932-43. doi:10.1002/art.24602
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