Recombinant Human CD320 protein (rFc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
C-rFc
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CD320 protein Ser36-Tyr229 (Accession# Q9NPF0-1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 51293 |
| 蛋白编号 | Q9NPF0-1 |
| 预测分子量 | 46.0 kDa |
| SDS-PAGE | 55-70 kDa, reducing (R) condition |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD320, also known as 8D6, 8D6A, or TCblR, is a single-pass type I membrane protein containing 2 LDL-receptor class A domains. Expressed abundantly on follicular dendritic cells (FDCs), CD320 has been shown to enhance the proliferation of germinal center (GC) B cells. It is the receptor for cellular uptake of transcobalamin-bound cobalamin. Defects in CD320 are the cause of methylmalonic aciduria type TCblR (MMATC).
参考文献:
1. Edward V Quadros. et al. (2009). Blood. 113(1):186-192. 2. Edward V Quadros. et al.(2013). Biochimie. 95(5):1008-1018. 3. Quadros EV. et al. (2005). Biochem Biophys Res Commun. 327:1006-1010.
