Recombinant Mouse BMP-9 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse BMP-9 protein Lys23-Arg428 (Accession# Q9WV56) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 12165 |
| 蛋白编号 | Q9WV56 |
| 预测分子量 | 70.9 kDa |
| SDS-PAGE | 38-44 kDa and 77-90 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Bone Morphogenetic Protein 9 (BMP9), also known as Growth Differentiation Factor 2 (GDF-2), is a cytokine belonging to the transforming growth factor-β (TGF-β) superfamily. BMP9 is mainly produced by hepatocytes and hepatic stellate cells in the liver and is secreted into the bloodstream, where it acts as a circulating factor involved in various physiological processes. BMP9 is synthesized as a precursor protein (pre-proBMP9) composed of 429 amino acids (aa) that includes a 22 aa signal peptide, a 297 aa prodomain (33 kDa) and a 110 aa mature protein (12.5 kDa). It is then cleaved by serine endoproteases, leading to a short dimeric mature form of 25 kDa, and the prodomain which can remain noncovalently associated with the mature short form, giving a size of about 100 kDa.
参考文献:
1. Bidart, Marie et al. Cellular and molecular life sciences : CMLS vol. 69,2 (2012): 313-24. 2. Song, J J et al. Endocrinology vol. 136,10 (1995): 4293-7. 3. Nolan-Stevaux, Olivier et al. PloS one vol. 7,12 (2012): e50920.
