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Recombinant Mouse OLR1/LOX1 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2473

Print datasheet

Synonyms

Lectin-like oxidized LDL receptor 1, Lectin-like oxLDL receptor 1, Lectin-type oxidized LDL receptor 1, Lox1, LOX-1

验证数据展示

  • Purity of Recombinant Mouse OLR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse OLR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse OLR1 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse OLR1 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse OLR1 protein Arg60-Ile363 (Accession# Q9EQ09) with a rabbit IgG Fc tag at the C-terminus.
基因ID 108078
蛋白编号 Q9EQ09
预测分子量 61.0 kDa
SDS-PAGE 65-85 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

OLR1 (also known as LOX1) is the receptor of oxidized low-density lipoprotein (ox-LDL) and is mainly expressed in endothelial cells, macrophages, smooth muscle cells, platelets, fibroblasts, and neurons. OLR1 is almost undetectable under physiological conditions, but it is upregulated following exposure to several proinflammatory and proatherogenic stimuli and can be detected in animal and human atherosclerotic lesions. OLR1 is the major contributor to ox-LDL uptake, internalization, and degradation in various cells. OLR1 plays a role in metabolism, cardiovascular disease and cancer.

参考文献:

1.Pirillo A. et al. (2013) Mediators Inflamm. 2013:152786.
2.Jin P and Cong S. (2019) Clin Chim Acta. 491:24-29.
3.Zhang P.  et al. (2023) Oncoimmunology. 12(1):2203073. 
4.Wu L. et al. (2023) Int J Mol Sci. 24(16):12904.
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