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Recombinant Human ErbB3/HER3 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2245

Print datasheet

Synonyms

ERBB3, c erbB 3, c erbB3, EC:2.7.10.1, ErbB 3

验证数据展示

  • Purity of Recombinant Human ErbB3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human ErbB3 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human ErbB3 protein Ser20-Thr643 (Accession# P21860-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 2065
蛋白编号 P21860-1
预测分子量 94.9 kDa
SDS-PAGE 95-130 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Human epidermal growth factor receptor-3 (ERBB3) is a member of the ERBB receptor tyrosine kinases (RTKs) and is expressed in many malignancies. The importance of ErbB3 receptor tyrosine kinase in cancer progression, primary and acquired drug resistance, has become steadily evident since its discovery in 1989. ErbB3 overexpression in various solid organ malignancies is associated with shorter survival of patients.

参考文献:

1.Chen, Yutao et al. (2024) Cancer Lett. 599:217146.
2.Hafeez, Umbreen et al. (2020) Expert Rev Anticancer Ther. 20(12):1057-1074. 
3.Lin, Sue-Hwa et al. (2008) Clin Cancer Res. 14(12):3729-3736.