Recombinant Human Integrin alpha-1 beta-1 Heterodimer protein (rFc Tag & His Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
rFc Tag & His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human Integrin alpha-1 beta-1 heterodimer protein, Human Integrin alpha-1 protein Phe29-Pro1141 (Accession# P56199) with a rabbit IgG Fc tag at the C-terminus, Human Integrin beta-1 protein Gln21-Asp728 (Accession# P05556-1) with a his tag at the C-terminus. |
| 基因ID | 3672 and 3688 |
| 蛋白编号 | P56199 and P05556-1 |
| 预测分子量 | 149.4 kDa (Integrin alpha-1) and 79.4 kDa (Integrin beta-1) |
| SDS-PAGE | 150-220 kDa (Integrin alpha-1) and 90-120 kDa(Integrin beta-1), reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands. They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits. In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis. Integrin alpha-1 (ITGA1, CD49a) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen and laminin. This receptor is involved in cell-cell adhesion and may play a role in inflammation and fibrosis. Integrin alpha-1 is a transmembrane glycoprotein with an apparent molecular weight of 180-250 kDa, larger than the calculated molecular weight of 131 kDa.
参考文献:
1. Takada, Yoshikazu et al. Genome biology vol. 8,5 (2007): 215. 2. Harburger, David S, and David A Calderwood. Journal of cell science vol. 122,Pt 2 (2009): 159-63.
