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Recombinant Human Siglec-5/CD170 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1673

Print datasheet

Synonyms

SIGLEC5, CD170, CD33 antigen like 2, CD33 antigen-like 2, CD33L2

验证数据展示

  • Purity of Recombinant Human Siglec-5 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human Siglec-5 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Human Siglec-5 protein Glu17-Thr434 (Accession# O15389) with a rabbit IgG Fc tag at the C-terminus.
基因ID 8778
蛋白编号 O15389
预测分子量 72.6 kDa
SDS-PAGE 85-110 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

SIGLEC5, also known as sialic acid-binding immunoglobulin-like lectin 5, is a member of the Siglec family, which are a group of immunoglobulin-type lectins that mediate protein-carbohydrate interactions via sialic acids attached to glycoproteins or glycolipids. SIGLEC5 is part of the CD33-related subset of Siglecs (CD33rSiglecs) and inhibits the activation of several cell types, including monocytes, macrophages, and neutrophils. In addition, SIGLEC5 mediates sialic acid-dependent binding to human erythrocytes and soluble glycoconjugates, indicating its potential involvement in cell-cell interactions.

参考文献:

1. Vuchkovska A. et al. (2022). Immunology. 166(2):238-248.
2. Cornish AL. et al. (1998). Blood. 1998;92(6):2123-2132.
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