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Recombinant Human IL-3RB/CD131 protein (rFc Tag)

种属

Human

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg1662

Print datasheet

Synonyms

CSF2RB, CD131, CDw131, GM-CSF/IL-3/IL-5 receptor common beta subunit, IL3RB

验证数据展示

  • Purity of Recombinant Human IL-3RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IL-3RB was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Human IL-3RB protein Trp17-Trp443 (Accession# P32927-1) with a rabbit IgG Fc tag at the C-terminus.
基因ID 1439
蛋白编号 P32927-1
预测分子量 75.0 kDa
SDS-PAGE 75-100 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CSF2RB, also known as CD131, IL3RB, IL5RB, SMDP5, and CDw131, is a gene in humans that encodes the beta chain of the receptor for granulocyte-macrophage colony-stimulating factor (GM-CSF), as well as IL-3 and IL-5. The protein is a transmembrane receptor that plays a role in immune response and controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. In unstimulated conditions, CSF2RB interacts constitutively with JAK1, and ligand binding leads to JAK1 stimulation and subsequent activation of the JAK-STAT pathway (PMID: 1495999; 9516124).

参考文献:

1. Tavernier J. et al. (1992). Proc Natl Acad Sci U S A. 89(15):7041-7045.
2. Ogata N. et al. (1998). Blood. 91(7):2264-2271.