Recombinant Mouse 2B4/CD244/SLAMF4 protein (His Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse 2B4/CD244/SLAMF4 protein Gln20-Pro226 (Accession# Q07763-1) with a His tag at the C-terminus. |
| 基因ID | 18106 |
| 蛋白编号 | Q07763-1 |
| 预测分子量 | 24.5 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD244, also known as SLAMF4 or 2B4, is a type I transmembrane glycoprotein belonging to the signaling lymphocyte activation molecule (SLAM) family. It consists of an extracellular segment with two immunoglobulin (Ig)-like domains, a transmembrane region, and a cytoplasmic domain containing tyrosine-based motifs. CD244 is present on natural killer (NK) cells, γδ T cells, a subset of CD8+ T cells, monocytes, basophils, dendritic cells, and myeloid-derived suppressor cells (MDSCs). It binds to CD48 with high affinity and transmits stimulatory or inhibitory signals that regulate immune function.
参考文献:
1. Alexander David Barrow. et al. (2019) Front Immunol. 10:909. 2. M H Brown. et al. (1998) J Exp Med.188(11):2083-90. 3. Laura Agresta. et al. (2018) Front Immunol. 9:2809. 4. M H Brown. et al. (1998) J Exp Med. 188(11):2083-90.
