Recombinant Mouse Endoglin/CD105 protein (His Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Endoglin/CD105 protein Glu27-Lys580 (Accession# Q63961) with a His tag at the C-terminus. |
| 基因ID | 13805 |
| 蛋白编号 | Q63961 |
| 预测分子量 | 60.9 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Endoglin (ENG, CD105) is a homodimeric cell membrane glycoprotein of 180 kDa, composed of disulphide-linked subunits of 90-95 kDa. Endoglin is a proliferation-associated and hypoxia-inducible protein mainly expressed on vascular endothelial cells. It acts as an accessory receptor for transforming growth factor beta (TFG-β) and is involved in vascular development and remodelling. The important role of Endoglin in angiogenesis and in tumor progression makes it an ideal target for antiangiogenic therapy and a good marker for tumor prognosis.
参考文献:
1. Cheifetz, S et al. The Journal of biological chemistry vol. 267,27 (1992): 19027-30. 2. Fonsatti, Ester et al. Oncogene vol. 22,42 (2003): 6557-63. 3. Nassiri, Farshad et al. Anticancer research vol. 31,6 (2011): 2283-90. 4. Duff, Sarah E et al. FASEB journal vol. 17,9 (2003): 984-92.
