Recombinant Mouse SHH protein (His Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
His Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse SHH protein Cys25-Gly198 (Accession# Q62226, Arg29His) with a His tag at the C-terminus. |
| 基因ID | 20423 |
| 蛋白编号 | Q62226 |
| 预测分子量 | 20.6 kDa |
| SDS-PAGE | 19-21 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Sonic Hedgehog (Shh) is a fundamental secreted glycoprotein that acts as a key morphogen during embryonic development and plays complex roles in adult tissue homeostasis and disease. Shh is a master regulator of cell fate, proliferation, and survival. Dysregulation of the Shh pathway is a direct cause of several severe conditions, making it a prime therapeutic target.
参考文献:
1. Samkari, Ayman et al. Expert review of neurotherapeutics vol. 15,7 (2015): 763-70. 2. Lopez-Rios, Javier. Seminars in cell & developmental biology vol. 49 (2016): 116-24. 3. Wang, Xiang-Zhi et al. Journal of the Chinese Medical Association : JCMA vol. 82,5 (2019): 343-350.
