Recombinant Human LEP protein (hIGg2fc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
hIGg2fc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human LEP protein Val22-Cys167 (Accession# P41159) with a hIGg2fc Tag at the N-terminus. |
| 基因ID | 3952 |
| 蛋白编号 | P41159 |
| 预测分子量 | 43.1 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Leptin is a protein hormone predominantly produced by adipocytes, with key roles in regulating appetite, energy balance, and neuroendocrine function. It signals to the brain, particularly the hypothalamus, to control feeding behavior and energy expenditure. Leptin levels rise after eating, indicating high energy reserves and reducing appetite, while they drop during fasting, stimulating hunger. Additionally, Leptin influences immune function by modulating inflammatory cytokine production and contributing to metabolic homeostasis. Abnormalities in Leptin levels are associated with conditions such as obesity, malnutrition, cardiovascular events, and infertility.
参考文献:
1. Obradovic, Milan et al. Frontiers in endocrinology vol. 12 585887. 18 May. 2021. 2. Pereira, Sandra et al. Endocrine reviews vol. 42,1 (2021): 1-28. 3. Perakakis, Nikolaos et al. Journal of the American College of Cardiology vol. 77,6 (2021): 745-760. 4. Picó, Catalina, and Mariona Palou. Nutrients vol. 14,1 114. 28 Dec. 2021.