Recombinant Human CEACAM5 protein (hIGg2fc Tag)
种属
Human
纯度
>90 %, SDS-PAGE
标签
hIGg2fc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <1.0 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human CEACAM5 protein Lys35-Ala685 (Accession# BC034671) with a hIGg2fc tag at the C-terminus. |
| 基因ID | 1048 |
| 蛋白编号 | BC034671 |
| 预测分子量 | 98.4 kDa |
| SDS-PAGE | |
| 组分 | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CEACAM5 is a cell surface glycoprotein that is overexpressed in a variety of human tumors, including pancreatic cancers, breast cancers, lung cancer, and neuro-endocrine prostate cancer (NEPC) and has been functionally associated with tumor differentiation, invasion, and metastasis. Currently, CEACAM5 has been targeted for developing immunotherapies such as bispecific T cell engagers (BiTEs), CAR-T cells, or ADCs.
参考文献:
1. Han, Zi-Wen et al. Investigational new drugs vol. 38,6 (2020): 1888-1898. 2. DeLucia, Diana C et al. Clinical cancer research : an official journal of the American Association for Cancer Research vol. 27,3 (2021): 759-774. 3. Kim, Ye-Jin et al. Frontiers in oncology vol. 13 1124039.