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验证数据展示

  • FC experiment of human peripheral blood leukocytes using 98061-1-RR

    FC experiment of human peripheral blood leukocytes using 98061-1-RR

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM1/3/6 (CD66a/c/d) Rabbit Recombinant Antibody (98061-1-RR, Clone:240497E12) or Isotype Control and PE-conjugated Goat Anti-Rabbit IgG. Cells were then stained with APC Anti-Human CD16. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • FC experiment of human peripheral blood leukocytes using 98061-1-RR

    FC experiment of human peripheral blood leukocytes using 98061-1-RR

    1x10^6 human peripheral blood leukocytes were surface stained with 0.25 ug Anti-Human CEACAM1/3/6 (CD66a/c/d) Rabbit Recombinant Antibody (98061-1-RR, Clone:240497E12) (red) or Isotype Control (blue) and PE-conjugated Goat Anti-Rabbit IgG. Cells were incubated with FC Receptor Block prior to staining. Cells were not fixed.

  • Affinity and Kinetic Characterization of 98061-1-RR

    Affinity and Kinetic Characterization of 98061-1-RR

    Biolayer interferometry (BLl) kinetic assays of 98061-1-RR against Human CEACAM1/CD66a were performed. The affinity constant is 4.34 nM.

Anti-Human CEACAM1/3/6 (CD66a/c/d) Rabbit Recombinant Antibody

CEACAM1/3/6 (CD66a/c/d) Uni-rAbTM Recombinant Antibody for FC
Cat No. 98061-1-RR

产品说明书

CloneNo. 240497E12

宿主/亚型

Rabbit / IgG

种属反应性

human

应用

FC

别名

CD66a/c/d, CD66c, CEACAM3, CEACAM6, CEACAM1

缓冲液配方:  PBS and Azide
PBS and Azide
PBS Only
偶联物:  Unconjugated
Unconjugated
规格: 

-/ -

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经过测试的应用

Positive FC detected inhuman peripheral blood leukocytes

推荐稀释比

应用推荐稀释比
This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

产品信息

98061-1-RR targets CEACAM1/3/6 (CD66a/c/d) in FC applications and shows reactivity with human samples.

经测试应用 FC Application Description
经测试反应性 human
免疫原 Recombinant protein 种属同源性预测
宿主/亚型 Rabbit / IgG
抗体类别 Recombinant
产品类型 Antibody
全称 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
别名 CD66a/c/d, CD66c, CEACAM3, CEACAM6, CEACAM1
计算分子量 526 aa, 58 kDa
GenBank蛋白编号BC014473
基因名称 CEACAM1
Gene ID (NCBI) 634
RRIDAB_3672208
偶联类型 Unconjugated
形式 Liquid
纯化方式Protein A purfication
UNIPROT IDP13688
储存缓冲液 PBS with 0.09% sodium azide , pH 7.3
储存条件Store at 2 - 8°C. Stable for one year after shipment.

背景介绍

CEACAM1, also known as CD66a or BGP (biliary glycoprotein), is a member of the cacinoembryonic antigen (CEA) family which belongs to the immunoglobulin superfamily of cell adhesion molecules (PMID: 16919437). CEACAMs play major roles in cell-cell and cell-ECM adhesion and have been implicated in the control of cell proliferation, angiogenesis, and tissue remodeling (PMID: 23021083). CEACAM1 is a transmembrane glycoprotein that is expressed on epithelial, endothelial, and immune cells (PMID: 30314283). CEACAM1 has been demonstrated to play a role in morphogenesis, apoptosis, angiogenesis, cell proliferation, cell motility, fibrosis, and immunity (PMID: 31604530). This antibody is raised against 35-428 aa of human CEACAM1/CD66a and can cross-react with CEACAM6/CD66c and CEACAM3/CD66d.

实验方案

Product Specific Protocols
FC protocol for CEACAM1/3/6 (CD66a/c/d) antibody 98061-1-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols