验证数据展示
产品信息
88658-1-PBS targets Trem2 as part of a matched antibody pair:
MP03622-1: 88658-1-PBS capture and 88658-2-PBS detection (validated in Cytometric bead array)
Unconjugated rabbit recombinant monoclonal antibody in PBS only (BSA and azide free) storage buffer at a concentration of 1 mg/mL, ready for conjugation. Created using Proteintech’s proprietary in-house recombinant technology. Recombinant production enables unrivalled batch-to-batch consistency, easy scale-up, and future security of supply.
This conjugation ready format makes antibodies ideal for use in many applications including: ELISAs, multiplex assays requiring matched pairs, mass cytometry, and multiplex imaging applications.Antibody use should be optimized by the end user for each application and assay.
| 经测试应用 | WB, Cytometric bead array, Indirect ELISA Application Description |
| 经测试反应性 | mouse |
| 免疫原 |
CatNo: Eg10946 Product name: Recombinant Mouse TREM2 protein (rFc Tag) Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 19-171 aa of NM_031254.4 Sequence: LNTTVLQGMAGQSLRVSCTYDALKHWGRRKAWCRQLGEEGPCQRVVSTHGVWLLAFLKKRNGSTVIADDTLAGTVTITLKNLQAGDAGLYQCQSLRGREAEVLQKVLVEVLEDPLDDQDAGDLWVPEESSSFEGAQVEHSTSRNQETSFPPTS 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | triggering receptor expressed on myeloid cells 2 |
| 别名 | TREM-2, Trem2a, Trem2b, Trem2c, Triggering receptor expressed on monocytes 2 |
| 计算分子量 | 25 kDa |
| 观测分子量 | 27 kDa, 30 kDa |
| GenBank蛋白编号 | NM_031254.4 |
| 基因名称 | Trem2 |
| Gene ID (NCBI) | 83433 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purification |
| UNIPROT ID | Q99NH8-1 |
| 储存缓冲液 | PBS only, pH 7.3. |
| 储存条件 | Store at -80°C. The product is shipped with ice packs. Upon receipt, store it immediately at -80°C |
背景介绍
Trem2 (triggering receptor expressed on myeloid cells 2), a trigger receptor 2 expressed by myeloid cells, is an important immunoregulatory receptor, mainly expressed on the surface of myeloid cells such as macrophages and microglia, and plays a key role in maintaining immune homeostasis, regulating inflammation and the occurrence and development of various diseases. Trem2 is highly expressed in tumor-associated macrophages (TAMs), which plays a role in promoting tumor by inhibiting anti-tumor immunity and promoting tumor angiogenesis, thus becoming a potential target of tumor immunotherapy. The protein has glycosylation modification.
