验证数据展示
经过测试的应用
| Positive WB detected in | SH-SY5Y cells, Neuro-2a cells, HeLa cells, A549 cells |
推荐稀释比
| 应用 | 推荐稀释比 |
|---|---|
| Western Blot (WB) | WB : 1:500-1:2000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
产品信息
84695-1-RR targets Integrin alpha 11 in WB, ELISA applications and shows reactivity with human, mouse samples.
| 经测试应用 | WB, ELISA Application Description |
| 经测试反应性 | human, mouse |
| 免疫原 | Peptide 种属同源性预测 |
| 宿主/亚型 | Rabbit / IgG |
| 抗体类别 | Recombinant |
| 产品类型 | Antibody |
| 全称 | integrin, alpha 11 |
| 别名 | ITGA11, Integrin alpha-11, 241351B7 |
| 计算分子量 | 133 kDa |
| 观测分子量 | 170 kDa |
| GenBank蛋白编号 | NM_001004439 |
| 基因名称 | ITGA11 |
| Gene ID (NCBI) | 22801 |
| RRID | AB_3672111 |
| 偶联类型 | Unconjugated |
| 形式 | Liquid |
| 纯化方式 | Protein A purfication |
| UNIPROT ID | Q9UKX5 |
| 储存缓冲液 | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| 储存条件 | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
背景介绍
The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID:19118207). Integrin alpha 11 (ITGA11) combines with the beta 1 subunit (ITGB1, CD29) to form a cell-surface receptor for collagen. This receptor is involved in cell migration and collagen reorganization on mesenchymal nonmuscle cells (PMID: 11518510). It is also involved in the regulation of myofibroblast phenotypic differentiation during fibrotic diseases (PMID: 29147013).
实验方案
| Product Specific Protocols | |
|---|---|
| WB protocol for Integrin alpha 11 antibody 84695-1-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |