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Recombinant Mouse CD93 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90%, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg3116

Print datasheet

Synonyms

Aa4, C1q/MBL/SPA receptor, C1qR(p), C1qr1, C1qRp

验证数据展示

  • Purity of Recombinant Mouse CD93 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CD93 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse CD93 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse CD93 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90%, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse CD93 protein Ala23-Asn572 (Accession# O89103) with a rabbit IgG Fc tag at the C-terminus.
基因ID 17064
蛋白编号 O89103
预测分子量 85.1 kDa
SDS-PAGE 110-120 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD93 (also known as complement protein 1 q subcomponent receptor C1qR1 or C1qRp) is a transmembrane glycoprotein consisting of 652 amino acids. CD93 can exist in two forms: soluble (sCD93) and membrane-bound (CD93). CD93 is expressed predominantly on endothelial cells, where it plays a key role in the promotion of angiogenesis in physiology and disease. CD93 is also highly expressed in tumor-associated blood vessels, and its presence is associated with poor prognosis, poor response to immunotherapy, immune cell infiltration, and high tumor, lymph node, and metastasis (TNM) stages in many cancer types. (PMID: 37443812) Targeting CD93-related signaling pathways in the tumor microenvironment may be a novel therapeutic strategy for tumor immunotherapy.

参考文献:

1. Tossetta G, et al. Cells. 2023;12(13):1778.                                                               
2. Sun Y, et al. Sci Transl Med. 2021;13(604):eabc8922.                                              
3. Guo A, et al. Front Immunol. 2022;13:907182. 
4. Wu B,et al. Front Immunol. 2023;14:984816.
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