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Recombinant Rat RANK/TNFRSF11A protein (rFc Tag)

种属

Rat

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg3285

Print datasheet

Synonyms

CD265, Osteoclast differentiation factor receptor (ODFR), RANK, Receptor activator of NF-KB, TNF receptor superfamily member 11A

验证数据展示

  • Purity of Recombinant Rat RANK was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Rat RANK was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Rat RANK protein Val31-Gln209 (Accession# F1M8Z6) with a rabbit IgG Fc tag at the C-terminus.
基因ID 498206
蛋白编号 F1M8Z6
预测分子量 45.9 kDa
SDS-PAGE 48-60 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

TNFRSF11A (tumor necrosis factor receptor superfamily, member 11A), also known as receptor activator of NF-κB (RANK), is highly expressed in bone and has an important role in osteoclast differentiation and activity. Tnfrsf11a deficiency in mice has also been associated with severe abnormalities in thymic epithelial cells and impaired negative selection, with severe autoimmune manifestations. Overexpression of RANK/TNFRSF11A in glioblastoma cell lines leads to a significant reduction in focus formation and elevated apoptotic activity.

参考文献:

1. Hughes A.E., et al. (2000). Nat Genet. Jan;24(1):45-48. 
2. von dem Knesebeck A, et al. (2012). Neoplasia. Jun;14(6):526-34.
3. Guerrini M.M., et al. (2008). Am J Hum Genet. Jul;83(1):64-76.