Recombinant Rat Serpin E1/PAI-1 protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat PAI-1 protein Ser24-Pro402 (Accession# P20961) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 24617 |
| 蛋白编号 | P20961 |
| 预测分子量 | 68.9 kDa |
| SDS-PAGE | 70-80 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
PAI-1 (Plasminogen Activator Inhibitor-1), also known as Serpin E1, is a member of the serine protease inhibitor (SERPIN) family. PAI-1, a single-chain glycoprotein of approximately 52 kDa, acts as an inhibitor of tissue plasminogen activator and urokinase-type plasminogen activator and affects fibrinolysis and plays an important role in lung diseases. Because PAI-1 may display cell type-specific glycosylation and activity, the glycosylation pattern of PAI-1 may serve as a potential biomarker for predicting cellular dysfunction and risk of thrombosis. Recent studies have revealed that PAI-1 has a pro-tumorigenic role in human cancers by regulating angiogenesis and tumor cell survival. It is suggested that increased vascular PAI-1 can directly accelerate the process of atherosclerotic thrombosis by promoting the formation of neointimal plaques.
参考文献:
1. Altalhi R, et al. (2021) Int J Mol Sci. 22(6):3170. 2. Ali G, et al. (2023) Stem Cell Res Ther. 14(1):185. 3. Furuya H, et al. (2022) Sci Rep. 12(1):12186.
