Recombinant Rat Fas Ligand/CD178 protein (mFc Tag)
种属
Rat
纯度
>85 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >85 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat Fas Ligand protein His103-Leu278 (Accession# P36940) with a mouse IgG Fc tag at the N-terminus. |
| 基因ID | 25385 |
| 蛋白编号 | P36940 |
| 预测分子量 | 47.8 kDa |
| SDS-PAGE | 48-60 kDa , reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Fas Ligand (also known as FasL, CD95L and CD178) is a 40-kDa type II transmembrane protein that binds to Fas (CD95), a widely expressed glycosylated cell surface molecule of 45-52-kDa. Fas Ligand is primarily expressed by lymphocytes and other immune cell types, such as Natural Killer (NK) cells. These cells induce Fas signaling on cells targeted for removal by the immune system resulting in the activation of apoptosis in sensitive cells. Fas Ligand and Fas, play an essential role in deletion of peripheral T cells and in homeostasis of organ tissues such as liver.
参考文献:
1. Caulfield AJ , Lathem WW. (2014) PLoS Pathog. 10(8):e1004252. 2. Modiano JF, Bellgrau D. (2016) Discov Med. 21(114):109-116. 3. Haluck-Kangas A , Peter ME. (2023) Biochem Soc Trans. 51(1):21-29. 4. Schmid A. et al. (2024) Chemistry. 30(24):e202400120.
