Recombinant Rat DKK1 protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat DKK1 protein Thr32-His270 (Accession# A6I0Z0) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 293897 |
| 蛋白编号 | A6I0Z0 |
| 预测分子量 | 52.0 kDa |
| SDS-PAGE | 58-70 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Dickkopf-1 (DKK1) acts as a natural inhibitor of Wnt/β-catenin pathway, directly binds to the LRP5/6 receptor and Kremen-1/2, leading to internalization of the receptor complex and dampening of Wnt/β-catenin signaling. Dkk1 is abnormally expressed in tumor cells, and abnormal expression of Dkk1 can inhibit cell proliferation or induce apoptosis through pro-apoptotic factors. In vivo, knocking down of DKK1 in the local site of femoral heads in AONFH rats could result in enhanced bone formation and even restoring the blood supply of the femoral heads.
参考文献:
1. D'Amico L, et al. (2016). J Exp Med. May 2;213(5):827-840. 2. Chen J, et al. (2021). Am J Transl Res. Apr 15;13(4):2320-2330. 3. Zhu G, et al. (2021). Cancer Manag Res. Jan 25;13:659-675.
