Recombinant Rat DDR1 protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Rat DDR1 protein Asp22-Thr413 (Accession# A6KT95) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 25678 |
| 蛋白编号 | A6KT95 |
| 预测分子量 | 69.9 kDa |
| SDS-PAGE | 70-85 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Discoidin Domain Receptor 1 (DDR1) is a receptor tyrosine kinase that is activated by fibrillar collagens, playing a pivotal role in cellular functions such as proliferation, differentiation, invasion, migration, survival, matrix remodeling, and cytokine expression. DDR1 is predominantly found in epithelial and smooth muscle cells, and its expression is mainly limited to epithelial cells located in several organs, including skin, kidney, liver, and lung. DDR1 has been implicated in a wide range of human diseases, including various types of cancer, fibrosis (such as liver/kidney/pulmonary fibrosis), inflammation, and atherosclerosis. High expression or mutation of DDR1 is associated with many cancers.
参考文献:
1. Liu M. et al. (2024). Eur J Med Chem. 268:116291. 2. Moll S. et al. (2019). Biochim Biophys Acta Mol Cell Res. 1866(11):118474. 3. Hou G. et al. (2002). Circ Res. 90(11):1147-1149.
