Recombinant Rat CD4 protein (rFc Tag)
种属
Rat
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 | Not tested |
| 来源 | HEK293-derived Rat CD4 protein Lys28-Thr394 (Accession# P05540) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 24932 |
| 蛋白编号 | P05540 |
| 预测分子量 | 67.4 kDa |
| SDS-PAGE | 70-85 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD4 is a 55-kDa transmembrane glycoprotein expressed on T helper cells, majority of thymocytes, monocytes, macrophages, and dendritic cells. CD4 is an accessory protein for MHC class-II antigen/T-cell receptor interaction. It plays an important role in T helper cell development and activation. CD4 serves as a receptor for the human immunodeficiency virus (HIV). CD4 triggering by gp120, a natural ligand of CD4, potentiates CD44-mediated adhesion to hyaluronic acid. CD4 is present in human and rat macrophages, but absent in mice.
参考文献:
1. K Bowers, et al. (1997) Int J Biochem Cell Biol. 29(6):871-5. 2. Gina Graziani-Bowering, et al. (2002) Exp Cell Res. 279(1):141-52. 3. J M Riberdy, et al. (1998) Proc Natl Acad Sci U S A. 95(8):4493-8. 4. U Dianzani, et al. (1999) Int Immunol. 11(7):1085-92. 5. P R Crocker, et al. (1987) J Exp Med. 166(2):613-8.