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Recombinant Pig IL-4 protein (rFc Tag)(HPLC verified)

种属

Pig

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg4866

Print datasheet

Synonyms

B-cell stimulatory factor 1, IL4, Interleukin-4

验证数据展示

  • Purity of Recombinant Pig IL-4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Pig IL-4 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Pig IL-4 was greater than 90% as determined by SEC-HPLC.

    The purity of Pig IL-4 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Pig IL-4 protein His25-Cys133 (Accession# Q04745) with a rabbit IgG Fc tag at the C-terminus.
基因ID 397225
蛋白编号 Q04745
预测分子量 38.8 kDa
SDS-PAGE 42-52 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Interleukin-4 (il-4), a member of the α-helical cytokine family, is produced by activated CD4+ T cells, basophils, and mast cells. It promotes the proliferation and differentiation of antigen presenting cells. Il4 also plays a pivotal role in antibody isotype switching and stimulates the production of IgE. This cytokine has been applied in the treatment of autoimmune disorder like multiple myeloma, cancer, psoriasis, and arthritis. Il4 has also been extensively applied to inhibit detrimental effect of Th1. It may promote the growth of epithelial tumors by mediating increased proliferation and survival.

参考文献:

1. Scheller J. et al. (1988). Behring Inst Mitt. (83):40-7.
2. Heinrich PC. et al. (2003). Biochem J. 374: 1-20.
3. Rose-John S. et al. (2007). Expert Opin Ther Targets. 11: 613-24.
4. Ming JE. et al. (1989). J Mol Cell Immunol. 4: 203-11.
5. Febbraio MA. et al. (2005). Exerc Sport Sci Rev. 33:114-9.
6. J Appl Physiol. et al. (2005). J Appl Physiol. 98:1154-62.