Recombinant Mouse Uromodulin protein (mFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
mFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse Uromodulin protein Asn25-Ala618 (Accession# Q91X17) with a mouse IgG Fc tag at the C-terminus. |
| 基因ID | 22242 |
| 蛋白编号 | Q91X17 |
| 预测分子量 | 92.0 kDa |
| SDS-PAGE | 110-130 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Uromodulin, also known as THP (Tamm-Horsfall glycoprotein), is the most abundant protein excreted in the urine under physiological conditions. Uromodulin is synthesized by the kidney and localizes in cells lining the ascending limb of Henle and the distal convoluted tubule. Uromodulin has been linked to water/electrolyte balance and to kidney innate immunity. Also, studies in knockout mice demonstrated that it has a protective role against urinary tract infections and renal stone formation. Mutations in the gene encoding uromodulin lead to rare autosomal dominant diseases, collectively referred to as uromodulin-associated kidney diseases.
参考文献:
1. Luca Rampoldi. et al. (2011) Kidney Int. 80(4):338-347. 2. Muchmore AV. et al.(1985) Science. 229: 479–481. 3. Easton RL. et al. (2000) J Biol Chem. 275: 21928–21938. 4. Jennings P. et al. (2007) J Am Soc Nephrol. 18: 264–273.
