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Recombinant Mouse TNFSF18 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2850

Print datasheet

Synonyms

GITR ligand, GITRL, Glucocorticoid-induced TNF-related ligand, Tnfsf18, Tumor necrosis factor ligand superfamily member 18

验证数据展示

  • Purity of Recombinant Mouse TNFSF18 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse TNFSF18 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse TNFSF18 protein Thr47-Ser173 (Accession# Q7TS55) with a rabbit IgG Fc tag at the C-terminus.
基因ID 240873
蛋白编号 Q7TS55
预测分子量 40.5 kDa
SDS-PAGE 39-48 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

TNFSF18 is also named as Glucocorticoid-induced TNF-related ligand (hGITRL). GITR is a gene coding for a member of the TNF receptor superfamily. GITR activation by its ligand (GITRL) influences the activity of effector and regulatory T cells, thus participating in the development of immune response against tumours and infectious agents, as well as in autoimmune and inflammatory diseases. GITR-GITRL interactions co-stimulate both responder T-cell functions and the suppressive functions of TReg cells. GITRL is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells.

参考文献:

1. Giuseppe Nocentini, et al. (2007) Eur J Immunol. 37(5):1165-9.
2. Ethan M Shevach, et al. (2006) Nat Rev Immunol. 6(8):613-8.
3. Pedro M L, et al. (2013) J Pharmacol Exp Ther. 347(1):164-72.