Recombinant Mouse LIGHT/CD258 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse LIGHT protein Asp72-Val239 (Accession# Q9QYH9) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 50930 |
| 蛋白编号 | Q9QYH9 |
| 预测分子量 | 44.4 kDa |
| SDS-PAGE | 45-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
TNFSF14 is a cytokine that plays a crucial role in T cell activation and the generation of cytotoxic T cells. It is also involved in the promotion of tumor metastasis and has potential applications in immunotherapy. Tnfsf14 is a member of the tumor necrosis factor (TNF) ligand family. It is a ligand for TNFRSF14, which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. It has been shown to stimulate the proliferation of T cells and trigger apoptosis of various tumor cells Mouse models have been used to study the function of Tnfsf14 in various disease states, and its human ortholog TNFSF14 is a promising candidate for the development of therapeutic strategies for cancer and autoimmune diseases.
参考文献:
1. Zhang N, Liu X, et al. (2023) Mol Ther. 31(9):2575-2590. 2. Wu Y, Zhan S, Chen L, et al. (2023) J Transl Med. 21(1):544. 3. Oranger A, Colaianni G, et al. (2024) Int J Mol Sci. 25(2):716. 4. Shi JW, Lai ZZ, et al. (2024) EMBO J. 43(21):5018-5036.
