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Recombinant Mouse CD134/OX40 protein (rFc Tag)

种属

Mouse

纯度

>90 %, SDS-PAGE

标签

rFc Tag

生物活性

未测试

Cat no : Eg2936

Print datasheet

Synonyms

CD134, Tnfrsf4, Ox40, OX40 antigen, OX40L receptor

验证数据展示

  • Purity of Recombinant Mouse CD134 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse CD134 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

产品信息

纯度 >90 %, SDS-PAGE
内毒素 <0.1 EU/μg protein, LAL method
生物活性 Not tested
来源 HEK293-derived Mouse CD134 protein Val20-Pro211 (Accession# P47741) with a rabbit IgG Fc tag at the C-terminus.
基因ID 22163
蛋白编号 P47741
预测分子量 47.3 kDa
SDS-PAGE 55-70 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

CD134, also known as OX40 and TNFRSF4, is a member of the TNFR-superfamily of receptors. It is a type I transmembrane protein predominantly expressed on activated T cells which include CD4 and CD8 T cells, Th2, Th1, and Th17 cells, as well as regulatory T cells (Tregs). CD134 is activated by its cognate ligand CD134L (OX40L) and functions as a T cell co-stimulatory molecule. CD134-CD134L interactions have been proposed as a potential therapeutic target for treating autoimmune diseases, cancer and infectious disease.

参考文献:

1. Paterson DJ. et al. (1987) Mol Immunol. 24(12):1281-1290. 
2. Roos A. et al. (1998) J Leukoc Biol. 64(4):503-510.
3. Croft M. (2010) Annu Rev Immunol. 28:57-78. 
4. Webb GJ. et al. (2016) Clin Rev Allergy Immunol. 50(3):312-332.