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Recombinant Mouse TIMP2 protein (rFc Tag)(HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2960

Print datasheet

Synonyms

Metalloproteinase inhibitor 2, Timp-2, Tissue inhibitor of metalloproteinases 2

验证数据展示

  • Purity of Recombinant Mouse TIMP2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse TIMP2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) conditions and stained using Coomassie blue.

  • The purity of Mouse TIMP2 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse TIMP2 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse TIMP2 protein Cys27-Pro220 (Accession# P25785) with a rabbit IgG Fc tag at the C-terminus.
基因ID 21858
蛋白编号 P25785
预测分子量 47.8 kDa
SDS-PAGE 44-50 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Metalloproteinases-2 (TIMP2) is a secreted protein ~21 kDa in size, primarily known for its role in regulating peripheral extracellular matrix (ECM) remodeling through its unique dual roles in regulating activation of latent matrix metalloproteinases (MMPs), including MMP2, to proteolytically active forms, and the inhibition of MMP activity.

参考文献:

1. Brew K. et al. (2010) Biochim Biophys Acta. 1803:55–71.
2. Caterina JJ. et al. (2000) J Biol Chem. 275:26416–22.
3. Wang Z. et al. (2000) J Biol Chem. 275:26411–5.