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Recombinant Mouse Reg2 protein (rFc Tag) (HPLC verified)

种属

Mouse

纯度

>90 %, SDS-PAGE
>90 %, SEC-HPLC

标签

rFc Tag

生物活性

未测试

Cat no : Eg2693

Print datasheet

Synonyms

Islet of Langerhans regenerating protein 2, Lithostathine-2, Pancreatic stone protein 2, Pancreatic thread protein 2, PSP

验证数据展示

  • Purity of Recombinant Mouse Reg2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Reg2 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse Reg2 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse Reg2 was greater than 90% as determined by SEC-HPLC.

产品信息

纯度 >90 %, SDS-PAGE
>90 %, SEC-HPLC
内毒素 <0.1 EU/μg protein, LAL method
生物活性 
Not tested
来源 HEK293-derived Mouse Reg2 protein Gln23-Ala173 (Accession# Q08731) with a rabbit IgG Fc tag at the C-terminus.
基因ID 19693
蛋白编号 Q08731
预测分子量 42.9 kDa
SDS-PAGE 40-46 kDa, reducing (R) conditions
组分 Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
复溶 Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
储存条件
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
运输条件 The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

背景信息

Regenerating islet-derived 2 (Reg2) is a trophic factor that stimulates β-cell replication and protects against islet destruction. Reg2 also serves as an islet autoantigen that induces autoimmune assaults on the islets and worsens diabetic progression. Injection of Reg2 protein into NOD mice can delay the course of diabetes at an early stage and improve the anti-apoptosis ability of pancreatic β cells.

参考文献:

1.Zhou YH,, et al. (2024) Biochem Pharmacol. 227:116444.
2.Yu L, et al. (2019) Diabetes Obes Metab. 21(5):1209-1222.
3.Huszarik K, et al. (2010) J Immunol. 185(9):5120-9.
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