Recombinant Mouse MGL2 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse MGL2 protein Ser72-Pro332 (Accession# Q8JZN1) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 216864 |
| 蛋白编号 | Q8JZN1 |
| 预测分子量 | 55.9 kDa |
| SDS-PAGE | 50-65 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
Macrophage galactose-type lectin (MGL) is a type II transmembrane glycoprotein belonging to the type II family of C-type lectin receptors (CLR). MGL is expressed on professional antigen presenting cells. In mice,there are two homologs of human MGL, MGL1(CD301a), and MGL2(CD301b). They contain the Gln–Pro–Asp (QPD) sequence in their carbohydrate recognition domain that facilitates galactose or N-acetylgalactosamine (GalNAc) recognition. Murine MGL1 was found to be highly specific for Lewis X and Lewis A structures, whereas mMGL2 recognized N-actetylgalactosamine (GalNAc) and galactose.
参考文献:
1.Singh SK, et al. (2009) Mol Immunol. 46(6):1240-9. 2.Denda-Nagai K, et al. (2010) J Biol Chem. 18;285(25):19193-204. 3.Zizzari IG, et al. (2015) J Immunol Res. 2015:450695.
