Recombinant Mouse LBP protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse LBP protein Gly25-Val481 (Accession# Q61805) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 16803 |
| 蛋白编号 | Q61805 |
| 预测分子量 | 76.7 kDa |
| SDS-PAGE | 80-90 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
LBP (Lipopolysaccharide-binding protein) is a 65 kDa type I acute response protein found in high concentrations in the blood and known to be of hepatic origin with antioxidant properties. It acts as an antioxidant to control lipid homeostasis and protects against oxidative stress by coupling with redox signaling and lipid metabolism. (PMID: 38615060) LBP inhibits monoamine biosynthesis by acting as an endogenous inhibitor of dopamine-β-hydroxylase (DBH) and aromatic-L-amino acid-decarboxylase (DDC), and targeting LBP may have therapeutic potential for some patients with depression.
参考文献:
1. Zhang Q, et al. Nat Commun. 2024; 3;15(1):3213. 2. Fang M, et al. Immunity. 2023;56(3):620-634.e11. 3. Milbank E,et al. Pharmacol Res. 2023;187:106562.
