Recombinant Mouse IL-28B/ IFNL3 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Human IL-28B protein Asp20-Val193 (Accession# Q8CGK6) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 338374 |
| 蛋白编号 | Q8CGK6 |
| 预测分子量 | 45.6 kDa |
| SDS-PAGE | 46-55 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IL-28B, also named as IFNL3, is a cytokine distantly related to type I interferons and the IL-10 family. IL-28B, interleukin 28A (IL-28A), and interleukin 29 (IL-29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL-10RB) and interleukin 28 receptor, alpha (IL-28RA). IL-28B was identified as a key regulator of B- and T-cell vaccine responses against influenza.
参考文献:
1. Sheppard P. et al. (2003). Nat Immunol. 4: 63-68. 2. Katrin Witte. et al. (2010). Cytokine Growth Factor Rev. 21(4):237-251. 3. Christabel Kelly. et al. (2011). Gut. 60(9):1284-1293. 4. Adrian Egli. et al. (2014). PLoS Pathog.10(12):e1004556.
