Recombinant Mouse IFN-alpha 11/IFNA11 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse IFN-alpha 11 protein Cys24-Ala190 (Accession# Q61716) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 15964 |
| 蛋白编号 | Q61716 |
| 预测分子量 | 45.2 kDa |
| SDS-PAGE | 46-50 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IFN-alpha 11 (Interferon-alpha Subtype 11) is a member of the type I interferon family, which includes multiple IFN-alpha subtypes and a single IFN-beta.All type I IFN subtypes are genetically highly conserved and bind to the same receptor (IFN-alpha/beta receptor, IFNAR), but they differ in their biological activity. IFN-α11 is induced to be expressed in response to viral infection, is Produced by macrophages and stimulating the production of protein kinases and oligoadenylate synthetases, it has antiviral and immunomodulatory functions. During viral infection, IFN-α11 stimulates natural killer (NK) cells to regulate antiviral effects and control retroviral infection.
参考文献:
1. Gibbert K, et al. PLoS Pathog. (2012);8(8):e1002868. 2. Fung MC, et al. J Immunol Methods. (2004); 284(1-2):177-86. 3. van Pesch V, et al. J Virol. (2004) ;78(15):8219-28.
