Recombinant Mouse IL-5RA/CD125 protein (hFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
hFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse IL-5RA protein Asp18-His339 (Accession# P21183) with a human IgG1 Fc tag at the C-terminus. |
| 基因ID | 16192 |
| 蛋白编号 | P21183 |
| 预测分子量 | 63.5 kDa |
| SDS-PAGE | 65-75 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
IL-5RA, also known as CD125, is a crucial component of the interleukin-5 receptor complex, which plays a significant role in the immune system, particularly in the regulation of eosinophil activity. Eosinophils are a type of white blood cell that are primarily involved in the body's response to parasitic infections and are also significantly implicated in allergic reactions and asthma. The interaction between interleukin-5 (IL-5) and its receptor IL-5RA is vital for the survival, activation, and differentiation of eosinophils.
参考文献:
1.Takaki S, et al. (1994). Mol Cell Biol. 14 (11):7404-13. 2.Barry SC, et al. (1991) Cytokine. 3(4):339-44. 3.dLawrence MG, et al. (2022) Ann Allergy Asthma Immunol.128 (1):53-60.e3.
