Recombinant Mouse IL-3RB/CD131 protein (rFc Tag)
种属
Mouse
纯度
>90 %, SDS-PAGE
标签
rFc Tag
生物活性
未测试
验证数据展示
产品信息
| 纯度 | >90 %, SDS-PAGE |
| 内毒素 | <0.1 EU/μg protein, LAL method |
| 生物活性 |
Not tested |
| 来源 | HEK293-derived Mouse IL-3RB protein His23-Trp441 (Accession# P26955) with a rabbit IgG Fc tag at the C-terminus. |
| 基因ID | 12983 |
| 蛋白编号 | P26955 |
| 预测分子量 | 74.7 kDa |
| SDS-PAGE | 70-90 kDa, reducing (R) conditions |
| 组分 | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| 复溶 | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| 储存条件 |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| 运输条件 | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
背景信息
CD131, also known as IL-3RB, IL-5RB, colony stimulating factor 2 receptor subunit beta (CSF2RB), or cytokine receptor common subunit beta, is the common subunit of the type I cytokine receptors for granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-3 and IL-5. It is expressed predominantly by hematopoietic cells but also by non-hematopoietic cells. CD131 mediates intracellular signaling by JAK2, leading to phosphorylation of CD131 and triggering signaling pathways such as STAT5, MAPK and PI3-Kinase/AKT which regulate cell survival, proliferation and function.
参考文献:
1. Beatriz F Côrte-Real, et al. (2022) Front Immunol. 13:1005965. 2. C L Scott, et al. (1999) Int J Biochem Cell Biol. 31(10):1011-5. 3. Timothy R Hercus, et al. (2013) Cytokine Growth Factor Rev. 24(3):189-201.
